Composite Nanoarchitectonics of Magnetic Silicon Dioxide-Modified Chitosan for Doxorubicin Delivery and In Vitro Cytotoxicity Assay

Abstract Developing drug delivery carriers for highly selective, controlled, and sustained release of the anti-cancer drugs is one crucial issues in cancer strive. We herein report synthesis Fe 3 O 4 (M) SiO 2 (S) nanoparticles their nanocomposites with chitosan (CS) high loading efficiency subsequent potentiality Doxorubicin (DOX) anticancer drug. The as-synthesized nanostructures were characterized using Fourier transform infrared (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), high-resolution transmission (HR-TEM), thermal analysis techniques. average crystallite sizes as-prepared M, S, CS/M, CS/S, CS/M/S found to be 5, 15, 70, 22, 29 nm, respectively. cumulative produced examined, results exhibited efficacy 71%, 95%, 96%, 79%, 17%, 42% CS, nanostructures, releasing revealed a promising percentages at pH 4.2 5 compared those 7.4. At 4.2, DOX-M, DOX-S, DOX-CS, DOX/M, DOX/CS/M/S 94%, 92%, 98%, While corresponding 97%, 90%, 46%, 43%, 70%. percentage DOX-CS/S was 60% though. in-vitro cytotoxicity M-DOX, CS-DOX, M/CS-DOX explored against two human cell lines (MCF-7 Hep-G2) SRB (Sulforhodamine B) assay. DOX-loaded M/CS highest its IC 50 values 2.65 2.25 μg/mL Hep-G2 MCF-7 lines, respectively, 5.1 4.5 free DOX. indicated that nanocomposite good candidate as nano-carrier